Electroporation-mediated intradermal delivery of DNA vaccines in nonhuman primates.
نویسندگان
چکیده
Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development of human vaccines, using noninvasive needleless electrodes.
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ورودعنوان ژورنال:
- Methods in molecular biology
دوره 1121 شماره
صفحات -
تاریخ انتشار 2014